OncoMatch/Clinical Trials/NCT06616597
Trial Targeting Gut Bacterial Androgen Production to Reverse Therapeutic Resistance to Abiraterone in Patients With Metastatic Prostate Cancer
Is NCT06616597 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Abiraterone acetate and Dexamethasone for prostate cancer (adenocarcinoma).
Treatment: Abiraterone acetate · Dexamethasone · Metronidazole — To determine if dexamethasone or dexamethasone plus metronidazole restore sensitivity to abiraterone for the treatment of metastatic prostate cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Disease stage
Metastatic disease required
Prior therapy
Must have received: abiraterone (abiraterone, prednisone)
PSA (+/- radiographic) progression after having been on abiraterone and prednisone for at least 12 weeks.
Must have received: LHRH agonist or orchiectomy
Must be maintained on a GnRH analogue or have undergone orchiectomy.
Cannot have received: investigational therapeutic or invasive surgical procedure (not including surgical castration)
Administration of an investigational therapeutic or invasive surgical procedure (not including surgical castration) within 30 days of Cycle 1 Day 1 or currently enrolled in an investigational drug study
Cannot have received: antibacterial therapy
On antibacterial therapy within 30 days prior to administration of study treatment.
Lab requirements
Liver function
Chronic liver disease with Child-Pugh class C cirrhosis; Bilirubin >3x ULN or AST and ALT >5x ULN
Cardiac function
Congenital prolonged QTc syndrome or QTc > 500 msec (non-paced rhythm)
Chronic liver disease with Child-Pugh class C cirrhosis (see calculator in protocol); Bilirubin >3x ULN or AST and ALT >5x ULN; Congenital prolonged QTc syndrome or QTc > 500 msec (non-paced rhythm)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Baltimore, Maryland
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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