OncoMatch/Clinical Trials/NCT06603402
Low-Dose Involved-Field Radiotherapy Plus Immunochemotherapy for ESCC
Is NCT06603402 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for esophageal squamous cell carcinoma (escc).
The aim of this clinical trial is to evaluate whether low-dose involved-field radiotherapy combined with immunochemotherapy can reduce treatment-related adverse effects, enhance progression-free survival (PFS), and improve overall survival (OS) in patients with locally advanced, unresectable esophageal squamous cell carcinoma. The key questions this study seeks to address are: * Can low-dose involved-field radiotherapy combined with immunochemotherapy reduce treatment-related adverse effects? * Does this combined approach improve PFS and OS in these patients? Participants in the study will: * Undergo an endoscopy at West China Hospital to confirm their diagnosis. * Receive a treatment regimen that includes low-dose radiotherapy at 45.0 Gy in 1.8 Gy per fraction over 25 fractions, alongside immunochemotherapy, with three cycles of chemotherapy administered every 3 weeks. * After completing the full treatment regimen, participants will undergo regular follow-up visits and monitoring by healthcare professionals.
Check if I qualifyExtracted eligibility criteria
Cancer type
Esophageal Carcinoma
Disease stage
Required: Stage III
Patients with locally advanced, unresectable ESCC who have received radical treatment (radical chemoradiotherapy or radical radiochemotherapy), including: Cervical esophagus involvement, T4 stage, supraclavicular lymph node metastasis, or inability to tolerate or refusal of surgery due to personal reasons; Failure of neoadjuvant or conversion therapy; Unresectable local recurrence after surgery (with measurable target lesions)
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: radical chemoradiotherapy
have received radical treatment (radical chemoradiotherapy or radical radiochemotherapy)
Lab requirements
Blood counts
Normal function of major organs
Kidney function
Normal function of major organs
Liver function
Normal function of major organs
Cardiac function
Normal function of major organs
Normal function of major organs
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify