OncoMatch/Clinical Trials/NCT06592599
Gemcitabine + Docetaxel + Toripalimab Induction in Epstein-Barr Virus (EBV) Associated Nasopharyngeal Carcinoma(NPC)
Is NCT06592599 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Toripalimab for nasopharyngeal carcinoma.
Treatment: Toripalimab — The purpose of the research is to test the safety and efficacy of the investigational drug in human subjects with cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Head and Neck Squamous Cell Carcinoma
Disease stage
Required: Stage T3-4, ANY N, ANY T, N1-3 (AJCC v8)
Locoregionally advanced EBV positive NPC (T3-4, any N OR any T, N1-3. No M1) per AJCC v 8
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: systemic anticancer treatment
Cannot have received: radiation therapy
Lab requirements
Blood counts
ANC ≥ 1,500 cells/mm3; Platelets ≥ 100,000 cells/mm3; Hemoglobin ≥ 8.0 g/dl (transfusion/intervention allowed)
Kidney function
Serum creatinine ≤ 1.5 mg/dl or calculated or measured creatinine clearance (CC) ≥ 50 ml/min
Liver function
Total bilirubin ≤ 1.5 x institutional ULN; AST and ALT ≤ 1.5 x institutional ULN
CBC/differential obtained within 21 days prior to day 1 of treatment, with adequate bone marrow function defined as follows: Absolute neutrophil count (ANC) ≥ 1,500 cells/mm3; Platelets ≥ 100,000 cells/mm3; Hemoglobin ≥ 8.0 g/dl (Note: The use of transfusion or other intervention to achieve Hgb ≥ 8.0 g/dl is acceptable.); Adequate hepatic function within 21 days prior to day 1 of treatment, defined as follows: Total bilirubin ≤ 1.5 x institutional ULN; AST and ALT ≤ 1.5 x institutional ULN; Adequate renal function within 21 days prior to day 1 of treatment, defined as follows: Serum creatinine ≤ 1.5 mg/dl or calculated or measured creatinine clearance (CC) ≥ 50 ml/min
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Stanford University · Palo Alto, California
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