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OncoMatch/Clinical Trials/NCT06589778

A Study of SHR-A2102 in Combination With Adebrelimab and SHR-8068 in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Is NCT06589778 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including SHR-A2102 and Adebelimab (SHR-1316) for non-small cell lung cancer.

Phase 1/2RecruitingShanghai Hengrui Pharmaceutical Co., Ltd.NCT06589778Data as of May 2026

Treatment: SHR-A2102 · Adebelimab (SHR-1316) · SHR-8068This study is a multicenter, open-label, dose-finding/efficacy-expanding Phase IB/II clinical trial to evaluate SHR-A2102 in combination with adebelimab in combination with SHR-8068 in patients with locally advanced or metastatic non-small cell lung cancer. The study consists of two phases: Phase IB to explore the safety/tolerability of SHR-A2102 in combination with adebelimab in combination with SHR-8068 in patients with locally advanced or metastatic non-small cell lung cancer; Phase II: To explore the efficacy of SHR-A2102 in combination with adebelimab in combination with SHR-8068 in patients with locally advanced or metastatic non-small cell lung cancer.

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: anti-tumor therapy

Exception: within 4 weeks prior to initiation of study treatment

Received anti-tumor therapy 4 weeks prior to initiation of study treatment

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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