OncoMatch/Clinical Trials/NCT06586242
Efficacy and Safety of Penpulimab Combined With Anlotinib and Chemotherapy
Is NCT06586242 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Penpulimab;Anlotinib;albumin paclitaxel;oxaliplatin;lobaplatin for esophageal cancer.
Treatment: Penpulimab;Anlotinib;albumin paclitaxel;oxaliplatin;lobaplatin — This study is a two arm, randomized, prospective, multicenter study on the perioperative treatment of locally advanced resectable esophageal cancer with penpulimab combined with anlotinib hydrochloride and chemotherapy.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Chemotherapy
Cancer type
Esophageal Carcinoma
Disease stage
Required: Stage CT2N1-3M0, CT3N0-3M0, CT4N0-3M0, STAGE II-IVA (TNM)
clinical diagnosis is ct2n1-3m0 or ct3n0-3m0 or ct4n0-3m0, and the TNM stage is stage ii-iva
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Lab requirements
Blood counts
bone marrow function basically normal; significant myelosuppression [excluded]
Kidney function
kidney function basically normal
Liver function
liver function basically normal
Cardiac function
heart function basically normal; exclusion for myocardial ischemia/infarction, arrhythmia, cardiac insufficiency
the investigator assessed that the thyroid, lung, bone marrow, liver, kidney and heart functions were basically normal
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06586242 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
What disease stage is eligible?
Stage CT2N1-3M0 or CT3N0-3M0 or CT4N0-3M0 or STAGE II-IVA is required.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages