OncoMatch/Clinical Trials/NCT06565689
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of YK012
Is NCT06565689 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies YK012 for relapsed or refractory b-cell non-hodgkin lymphoma.
Treatment: YK012 — This study aims to provide a basis for further clinical development of YK012.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: rituximab (rituximab)
Participants have previously received rituximab Treatment (unless rituximab is intolerant)
Cannot have received: biologic targeted therapy
Treatment with biologic targeted therapy or anti-tumor immunotherapy within 4 weeks prior to the first dose of YK012
Cannot have received: anti-tumor immunotherapy
Treatment with biologic targeted therapy or anti-tumor immunotherapy within 4 weeks prior to the first dose of YK012
Cannot have received: chemotherapy
Participants who have received chemotherapy within 4 weeks prior to the first dose of YK012
Cannot have received: small molecule targeted agent
Participants who have received small molecule targeted agents within 2 weeks or 5 half-lives (whichever is longer) prior to the first dose of YK012
Cannot have received: investigational agent
Participants who have received other investigational agents within 4 weeks or 5 half-lives (whichever is shorter) prior to the first dose of YK012
Cannot have received: radiation therapy
Participants who have received radical/extensive radiotherapy within 4 weeks prior to the first dose of YK012, or local palliative radiotherapy within 2 weeks prior to the first dose of YK012, or acute toxicity induced by previous radiotherapy have not recovered to grade ≤1
Cannot have received: autologous stem cell transplant
Participants who have received autologous HSCT within 12 weeks prior to the first dose of YK012
Cannot have received: allogeneic stem cell transplant
Participants who have received allogeneic HSCT or organ transplant
Cannot have received: organ transplant
Participants who have received allogeneic HSCT or organ transplant
Cannot have received: CAR-T cell therapy
Participants who have received chimeric antigen receptor T cell (CAR-T) immunotherapy
Lab requirements
Blood counts
essentially normal function of hematology
Kidney function
essentially normal function of kidney
Liver function
essentially normal function of liver
Participants with essentially normal function of hematology, liver, and kidney function.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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