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OncoMatch/Clinical Trials/NCT06565689

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of YK012

Is NCT06565689 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies YK012 for relapsed or refractory b-cell non-hodgkin lymphoma.

Phase 1RecruitingExcyte Biopharma LtdNCT06565689Data as of May 2026

Treatment: YK012This study aims to provide a basis for further clinical development of YK012.

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Extracted eligibility criteria

Cancer type

Non-Hodgkin Lymphoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 2 prior lines

Must have received: rituximab (rituximab)

Participants have previously received rituximab Treatment (unless rituximab is intolerant)

Cannot have received: biologic targeted therapy

Treatment with biologic targeted therapy or anti-tumor immunotherapy within 4 weeks prior to the first dose of YK012

Cannot have received: anti-tumor immunotherapy

Treatment with biologic targeted therapy or anti-tumor immunotherapy within 4 weeks prior to the first dose of YK012

Cannot have received: chemotherapy

Participants who have received chemotherapy within 4 weeks prior to the first dose of YK012

Cannot have received: small molecule targeted agent

Participants who have received small molecule targeted agents within 2 weeks or 5 half-lives (whichever is longer) prior to the first dose of YK012

Cannot have received: investigational agent

Participants who have received other investigational agents within 4 weeks or 5 half-lives (whichever is shorter) prior to the first dose of YK012

Cannot have received: radiation therapy

Participants who have received radical/extensive radiotherapy within 4 weeks prior to the first dose of YK012, or local palliative radiotherapy within 2 weeks prior to the first dose of YK012, or acute toxicity induced by previous radiotherapy have not recovered to grade ≤1

Cannot have received: autologous stem cell transplant

Participants who have received autologous HSCT within 12 weeks prior to the first dose of YK012

Cannot have received: allogeneic stem cell transplant

Participants who have received allogeneic HSCT or organ transplant

Cannot have received: organ transplant

Participants who have received allogeneic HSCT or organ transplant

Cannot have received: CAR-T cell therapy

Participants who have received chimeric antigen receptor T cell (CAR-T) immunotherapy

Lab requirements

Blood counts

essentially normal function of hematology

Kidney function

essentially normal function of kidney

Liver function

essentially normal function of liver

Participants with essentially normal function of hematology, liver, and kidney function.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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