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OncoMatch/Clinical Trials/NCT06563362

Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma

Is NCT06563362 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for oropharynx cancer.

Phase 2RecruitingUniversity of ZurichNCT06563362Data as of May 2026

Multicentric prospective model-based de-escalation of the elective clinical target volumes (CTV) in radiotherapy of oropharyngeal carcinoma of all stages with the goal to reduce toxicity. The study investigates the feasibility of this approach as measured by the number of expected out-of-field recurrencies based on the individual patient's state of disease progression and risk factors

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Extracted eligibility criteria

Cancer type

Head and Neck Squamous Cell Carcinoma

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: surgery

Exception: Dissection of singular lymph nodes for diagnostic purposes before treatment start is allowed.

Previous surgery in head and neck region affecting the cervical lymphatic system. Dissection of singular lymph nodes for diagnostic purposes before treatment start is allowed.

Cannot have received: chemotherapy

Previous chemotherapy treatment for other head and neck cancers.

Cannot have received: radiotherapy

Previous radiotherapy treatment for other head and neck cancers.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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