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OncoMatch/Clinical Trials/NCT06560528

Disitamab Vedotin Combined With Tislelizumab and Capecitabine in the Perioperative Treatment of Locally Advanced Gastric Cancer With HER2 Overexpression

Is NCT06560528 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies combination with Disitamab Vedotin and with Tislelizumab and Capecitabine for gastric cancer.

Phase 2RecruitingTianjin Medical University Cancer Institute and HospitalNCT06560528Data as of May 2026

Treatment: combination with Disitamab Vedotin and with Tislelizumab and CapecitabineThe efficacy and safety of combination with Disitamab Vedotin and with Tislelizumab and Capecitabine for perioperative treatment of locally advanced gastric cancer with HER2 overexpression.

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Extracted eligibility criteria

Cancer type

Gastric Cancer

Esophageal Carcinoma

Biomarker criteria

Required: HER2 (ERBB2) overexpression (ihc 3+ or 2+)

Disease stage

Required: Stage Ⅱ, Ⅲ (AJCC 8th)

Clinical stage Ⅱ, Ⅲ (cT2-4a ,N+ or -, M0, AJCC 8th)

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: anti-tumor systemic therapy

Exception: adjuvant or neoadjuvant therapy allowed if completed >= 4 weeks before study and all adverse events recovered to ≤ CTCAE level 1 (except hair loss and pigmentation)

Patients who have received other anti-tumor systemic therapy in the past (including traditional Chinese medicine with anti-tumor indications), and have been less than 4 weeks from the completion of treatment to the administration of this study, or the adverse events caused by previous treatment have not recovered to ≤ CTCAE level 1 (except hair loss and pigmentation)

Lab requirements

Blood counts

Major organs are functioning normally

Kidney function

Major organs are functioning normally

Liver function

Major organs are functioning normally

Major organs are functioning normally

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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