OncoMatch/Clinical Trials/NCT06555068
A Trial of HRS-6209 in Combination With Fulvestrant, Letrozole, HRS-8080, or HRS-1358 in Breast Cancer Patients
Is NCT06555068 recruiting? Yes, currently enrolling (Sep 2026). This Phase 1/2 trial studies multiple treatments for advanced unresectable or metastatic breast cancer.
Treatment: HRS-6209 in Combination with Fulvestrant · HRS-6209 in Combination with HRS-1358 · HRS-6209 in Combination with Letrozole · HRS-6209 in Combination with HRS-8080 · HRS-6209 in Combination with HRS-9813 and Letrozole · HRS-6209 in Combination with HRS-9813 and HRS-8080 — The study is being conducted to evaluate the safety, PK and efficacy of HRS-6209 in Combination with Fulvestrant, Letrozole, HRS-8080, or HRS-1358 for advanced unresectable or metastatic breast cancer
Check if I qualifyExtracted eligibility criteria
Treatments studied
Endocrine / hormonal
Other
Cancer type
Breast Carcinoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Cannot have received: fulvestrant (fulvestrant)
Exception: for cohort of HRS-6209 in combination with fulvestrant (efficacy expansion stage)
Previous use of fulvestrant for cohort of HRS-6209 in combination with fulvestrant (efficacy expansion stage)
Lab requirements
Blood counts
Adequate organ and marrow function as defined by the protocol
Kidney function
Adequate organ and marrow function as defined by the protocol
Liver function
Adequate organ and marrow function as defined by the protocol
Adequate organ and marrow function as defined by the protocol
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06555068 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior fulvestrant disqualifies patients from enrollment.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Is this trial open to male patients?
No. This trial enrolls female patients only.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages