OncoMatch/Clinical Trials/NCT06555003
DEBIRI Plus Chemotherapy vs. Chemotherapy Alone in Colorectal Cancer Liver Metastases
Is NCT06555003 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies multiple treatments including Drug-Eluting Embolic Bead and Chemotherapy drug for liver neoplasm.
Treatment: Drug-Eluting Embolic Bead · Chemotherapy drug — A total of 116 patients who meet the inclusion criteria and are chemotherapy-naïve for their metastatic disease, will be randomly assigned to either the treatment group (DEBIRI plus systemic chemotherapy) or the control group (systemic chemotherapy alone). After 4 cycles of chemotherapy and 2 cycles of DEBIRI, patient reassessment to evaluate treatment response, based on RECIST criteria, will be performed using MRI or CT scan within 1-3 months of treatment initiation. The feasibility of secondary tumor resection, as primary endpoint, will be reassessed at a three-month follow-up multidisciplinary team (MDT) meeting, guided by established clinical guidelines.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Colorectal Cancer
Disease stage
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Lab requirements
Blood counts
absolute neutrophil count ≥ 1.5 × 10^9/l, platelet ≥ 75 ×10^9/l, international normalized ratio ≤ 1.3
Kidney function
creatinine ≤ 2.0 mg/dl
Liver function
total bilirubin ≤ 2.0 mg/dl, aspartate aminotransferase and alanine aminotransferase ≤ 5 × uln, albumin ≥ 2.5 g/dl
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06555003 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages