OncoMatch/Clinical Trials/NCT06552260
A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Is NCT06552260 recruiting? Yes, currently enrolling (May 2026). This Early Phase 1 trial studies Troriluzole for glioblastoma.
Treatment: Troriluzole — This research study is studying troriluzole as a possible treatment for recurrent glioblastoma. The name of the study drug involved in this research study is: -Troriluzole (a tripeptide prodrug of riluzole)
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Biomarker criteria
Required: IDH1 wild-type
Required: IDH2 wild-type
Disease stage
Required: Stage WHO GRADE 4 (WHO 2021)
Grade: 4 (WHO)
WHO Grade 4, and variants including gliosarcoma as per WHO 2021 criteria; Confirmed measurable disease per RANO 2.0 for GBM
Prior therapy
Must have received: radiation therapy
Prior treatment with radiotherapy with or without chemotherapy.
Cannot have received: troriluzole (troriluzole)
Prior treatment with troriluzole or riluzole
Cannot have received: riluzole (riluzole)
Prior treatment with troriluzole or riluzole
Lab requirements
Blood counts
ANC ≥ 1,500/mm3; Platelets ≥ 100,000/mm3; Hemoglobin ≥ 9 g/dL
Kidney function
Serum creatinine ≤ 1.5 mg/dL or creatinine clearance ≥ 60 mL/min
Liver function
Total bilirubin ≤ 2 × ULN (unless Gilbert's Syndrome, then < 5 mg/dL); AST/ALT ≤ 1.5 × ULN
Cardiac function
NYHA Functional Classification 2B or better
Laboratory values at the Screening Visit: ANC count < 1,500/mm3; Platelets <100,000/mm3; Hemoglobin < 9 g/dL; Total bilirubin > 2 × ULN (unless Gilbert's Syndrome, then < 5 mg/dL); AST > 1.5 x ULN; ALT > 1.5 x ULN; Serum creatinine > 1.5 mg/dL or creatinine clearance < 60 mL/min. Cardiac: NYHA Functional Classification 2B or better.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Brigham and Women's Hospital · Boston, Massachusetts
- Dana-Farber Cancer Institute · Boston, Massachusetts
- Massachusetts General Hospital Cancer Center · Boston, Massachusetts
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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