OncoMatch/Clinical Trials/NCT06528496
N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma
Is NCT06528496 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for high-risk neuroblastoma.
Treatment: DANYELZA · Sargramostim · Cytoxan · Topotecan · Vincristine · Doxorubicin · Ifosfamide · Etoposide · Carboplatin · Irinotecan · Temozolomide — The purpose of this study is to find out whether N10 chemotherapy is a safe and effective treatment for children with high-risk neuroblastoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Neuroblastoma
Biomarker criteria
Required: MYCN amplification
Disease stage
Required: Stage L2
Prior therapy
Lab requirements
Blood counts
No severe hematologic dysfunction (toxicity >= grade 3)
Kidney function
No severe renal dysfunction (toxicity >= grade 3)
Liver function
No severe hepatic dysfunction (toxicity >= grade 3)
Cardiac function
No severe cardiac dysfunction (toxicity >= grade 3)
Severe dysfunction of major organs, i.e., renal, cardiac, hepatic, neurologic, pulmonary, hematologic, or gastrointestinal toxicity >= to grade 3. Organ dysfunction due to direct effects of primary tumor or metastatic disease, or due to paraneoplastic syndromes associated with neuroblastoma, will not be considered in exclusion criteria. Similarly, complications of interventions to control above direct effects (e.g., steroid-induced hyperglycemia or hypertension) will also not be considered in exclusion criteria
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Memorial Sloan Kettering Cancer Center · New York, New York
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