OncoMatch/Clinical Trials/NCT06523673
Stereotactic Body Radiotherapy for Oligo-Progression Metastatic Non-Small Cell Lung Cancer
Is NCT06523673 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies second-line systemic therapy for metastatic non-small cell lung cancer.
Treatment: second-line systemic therapy — The goal of this clinical trial is to learn if Stereotactic Body Radiotherapy (SBRT) can treat the oligo-progressive metastatic non-small cell lung cancer (NSCLC) after first-line chemotherapy. The main questions it aims to answer are: Does SBRT improve progression-free survival in oligo-progressive metastatic non-small cell lung cancer after first-line chemotherapy? Does SBRT improve overall survival and quality of life in oligo-progressive metastatic non-small cell lung cancer after first-line chemotherapy? Researchers will compare SBRT in combination with standard of care (SOC) and SOC only to see if SBRT works to treat oligo-progressive metastatic non-small cell lung cancer after first-line chemotherapy. Participants will: Take SBRT in combination with SOC or SOC only. Visit the clinic for checkups and tests as required by the study. Keep a diary of their symptoms and complete the quality of life assessment questionnaire.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Allowed: ALK fusion
Allowed: EGFR mutation
Disease stage
Required: Stage IV
Metastatic disease required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: chemotherapy — first-line
Patients who had prior first-line chemotherapy with clinical benefit lasting for ≥3 months.
Cannot have received: investigational drug or device
have been treated with another investigational drug or investigational device that may affect this study within 4 weeks prior to first treatment
Lab requirements
Blood counts
normal bone marrow function
Kidney function
normal internal organ function
Liver function
normal internal organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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