OncoMatch/Clinical Trials/NCT06500455
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Is NCT06500455 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies non-drug interventions for anatomic stage iv breast cancer ajcc v8.
This phase III trial compares the effectiveness of fractionated stereotactic radiosurgery (FSRS) to usual care stereotactic radiosurgery (SRS) in treating patients with cancer that has spread from where it first started to the brain. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. FSRS delivers a high dose of radiation to the tumor over 3 treatments. SRS is a type of external radiation therapy that uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor. FSRS may be more effective compared to SRS in treating patients with cancer that has spread to the brain.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Non-Small Cell Lung Carcinoma
Tumor Agnostic
Melanoma
Renal Cell Carcinoma
Disease stage
Metastatic disease required
Prior therapy
Cannot have received: radiation therapy to the brain
No prior radiotherapy to the brain (partial or whole brain irradiation, SRS, FSRS, or prophylactic cranial irradiation [PCI])
Lab requirements
Liver function
no hepatic insufficiency resulting in clinical jaundice and/or coagulation defects
Cardiac function
new york heart association functional classification ii or better
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Banner University Medical Center - Tucson · Tucson, Arizona
- University of Arizona Cancer Center-North Campus · Tucson, Arizona
- University of Arkansas for Medical Sciences · Little Rock, Arkansas
- Kaiser Permanente-Anaheim · Anaheim, California
- Kaiser Permanente-Bellflower · Bellflower, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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