OncoMatch/Clinical Trials/NCT06493370
Intravenous Ascorbate Plus Gemcitabine/Carboplatin: A Novel and Cost-Effective Alternative With Evident Efficacy in Patients With Muscle Invasive Bladder Cancer
Is NCT06493370 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Intravenous ascorbic acid/vitamin C for bladder cancer.
Treatment: Intravenous ascorbic acid/vitamin C — This is a phase II, single arm, Simon two-stage design, trial, enrolling patients with cisplatin ineligible MIBC and/or those patients who decline cisplatin based NAC. Assess rates of pathologic downstaging and quality of life in MIBC cisplatin-ineligible/declined patients when IVC is added to gemcitabine-carboplatin NAC.
Check if I qualifyExtracted eligibility criteria
Cancer type
Urothelial Carcinoma
Biomarker criteria
Required: G6PD normal (normal)
Normal Glucose-6-phosphate dehydrogenase (G6PD) status
Excluded: G6PD deficiency
History of G6PD deficiency
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Lab requirements
Blood counts
Absolute Neutrophil Count >1.5K/UL (patients with benign neutropenia eligible with ANC 1000-1500 at physician discretion); Platelets >100K/UL; Hemoglobin ≥ 9 g/dL
Kidney function
Serum creatinine ≤ 1.5 x ULN or calculated creatinine clearance ≥ 30 mL/min using the Cockcroft-Gault equation
Liver function
Total bilirubin ≤ 2.0 x ULN; AST (SGOT) and ALT (SGPT) ≤ 2.5 x ULN unless liver metastases are present, in which case they must be ≤ 5 x ULN
Adequate organ function, defined as follows: Absolute Neutrophil Count >1.5K/UL... Platelets >100K/UL; Hemoglobin ≥ 9 g/dL; Serum creatinine ≤ 1.5 x ULN or calculated creatinine clearance ≥ 30 mL/min... Total bilirubin ≤ 2.0 x ULN; AST (SGOT) and ALT (SGPT) ≤ 2.5 x ULN unless liver metastases are present, in which case they must be ≤ 5 x ULN; Normal Glucose-6-phosphate dehydrogenase (G6PD) status
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Holden Comprehensive Cancer Center - The University of Iowa · Iowa City, Iowa
- The University of Kansas Cancer Center · Kansas City, Kansas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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