OncoMatch/Clinical Trials/NCT06492460
2 Courses of Concurrent Cisplatin Chemoradiotherapy After Surgery for High-risk Head and Neck Squamous Cell Carcinoma
Is NCT06492460 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies Drug：Cisplatin for squamous cell carcinoma of head and neck.
Treatment: Drug：Cisplatin — The main objective of this trial was to determine the value of 2 courses of cisplatin concurrent chemotherapy in postoperative adjuvant radiotherapy for high-risk head and neck squamous cell carcinoma.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Chemotherapy
Cancer type
Head and Neck Squamous Cell Carcinoma
Disease stage
Required: Stage III, IV
Demographics
Prior therapy
Must have received: surgery — radical
Radical surgery has been performed with high risk factors (one of below)
Cannot have received: chemotherapy
Exception: induction chemotherapy prior to surgery
Previous chemotherapy (except induction chemotherapy prior to surgery)
Cannot have received: radiation therapy
Previous radiation therapy
Lab requirements
Blood counts
WBC > 4×10^9/L; hemoglobin > 120g/L in males, 110g/L in females; platelet count > 100×10^9/L
Kidney function
creatinine clearance > 60 ml/min
Liver function
ALT, AST < 1.5x ULN; ALP < 2.5x ULN; bilirubin < ULN
Normal bone marrow function: white blood cell count > 4×10^9/L, hemoglobin > 120g/L in males, 110g/L in females, platelet count > 100×10^9/L. Normal liver function: ALT, AST < 1.5x ULN; ALP < 2.5x ULN; bilirubin < ULN. Normal renal function: creatinine clearance > 60 ml/min.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06492460 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior chemotherapy, radiation therapy disqualifies patients from enrollment.
What disease stage is eligible?
Stage III or IV is required.
Is there an age limit?
Yes. Patients must be 70 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages