OncoMatch/Clinical Trials/NCT06491680
Cardiotoxicity in Breast Cancer Patients
Is NCT06491680 recruiting? Yes, currently enrolling (Jun 2026). This Phase 4 trial studies Dapagliflozin 10mg Tab for breast cancer.
Treatment: Dapagliflozin 10mg Tab — The goal of this clinical trial is to learn if dapagliflozin drug has a cardioprotective effect against anthracyclines-induced cardiotoxicity. It will also learn about the safety of dapagliflozin drug. Aim of the study: Evaluate cardioprotective effect and safety of dapagliflozin against anthracyclines-induced cardiotoxicity. The main questions it aims to answer are: 1. Does the drug lower the cardiotoxicity which induced by anthracyclines? 2. What medical problems do participants have when taking dapagliflozin drug? Treatment 1. Anthracyclines by 4 cycles included doxorubicin 50-60 mg/m2 with cyclophosphamide 600 mg as a combination or epirubicin 90-100 mg/m2 with cyclophosphamide 600 mg as a combination. 2. Dapagliflozin 10 mg tablet orally, once daily. Started 7 days before the first cycle of anthracyclines till the end of last anthracyclines dose.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Breast Carcinoma
Demographics
Prior therapy
Cannot have received: anthracycline-containing regimen
Previous anthracycline-containing regimens
Cannot have received: cardiotoxic chemotherapy
any cardiotoxic chemotherapy regimens
Lab requirements
Kidney function
egfr > 30 ml/minute per 1.73 m2
Cardiac function
lvef > 50%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06491680 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior anthracycline-containing regimen, cardiotoxic chemotherapy disqualifies patients from enrollment.
Is there an age limit?
Yes. Patients must be 60 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages