OncoMatch/Clinical Trials/NCT06484790
T Cell Receptor Gene-Engineered T Cell Therapy Targeting KRAS Mutations in the Treatment of Subjects With Advanced Solid Tumor
Is NCT06484790 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including NW-301V and NW-301D for tumor, solid.
Treatment: NW-301V · NW-301D — An open label, two-cohort, dose-escalation clinical study to evaluate the safety, anti-tumor activity and pharmacokinetics/pharmacodynamic (PK/PD) of NW-301V and NW-301D in subjects with advanced solid tumor.
Check if I qualifyExtracted eligibility criteria
Biomarker criteria
Required: HLA-A A11:01 positive
HLA-A11:01positive
Required: KRAS G12V
Tumor has KRAS G12V (NW-301V cohort)
Required: KRAS G12D
Tumor has KRAS ... G12D (NW-301D cohort)
Performance status
ECOG 0–1(Restricted strenuous activity)
Lab requirements
Blood counts
Adequate organ function prior to apheresis and lymphodepleting chemotherapy
Kidney function
Adequate organ function prior to apheresis and lymphodepleting chemotherapy
Liver function
Adequate organ function prior to apheresis and lymphodepleting chemotherapy
Adequate organ function prior to apheresis and lymphodepleting chemotherapy
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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