OncoMatch/Clinical Trials/NCT06479239
Study of EGFRBi Armed Fresh PBMC in Metastatic or Unresectable Pancreatic Cancer
Is NCT06479239 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies EGFR FPBMC for pancreas cancer.
Treatment: EGFR FPBMC — The purpose of this study is to understand the safety and estimate the efficacy of combining anti-cluster of differentiation 3 (CD3) x anti-Epidermal Growth Factor Receptor (EGFR) bispecific antibody fresh peripheral blood mononuclear cells (EGFR FPBMC) for patients with metastatic or unresectable pancreas cancer. Participants receive 8 twice weekly doses and then 8 more doses every 2 weeks of EGFR FPBMC by intravenous infusion.
Check if I qualifyExtracted eligibility criteria
Cancer type
Pancreatic Cancer
Disease stage
Required: Stage III, IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: chemotherapy (gemcitabine, 5FU, capecitabine, albumin-bound paclitaxel)
Therapy should consist of either a gemcitabine, 5FU-based (including capecitabine) or albumin-bound paclitaxel-based regimen
Cannot have received: investigational agent
Treatment with investigational agent within 3 weeks prior to registration
Lab requirements
Blood counts
absolute neutrophil count >= 500/mm3; absolute lymphocyte count >= 400/mm3; platelets >= 75,000/mm3; hemoglobin >= 8 g/dl
Kidney function
serum creatinine < 2.0mg/dl or calculated/measured creatinine clearance >= 50 ml/min
Liver function
bilirubin <= 2 mg/dl; ast and alt <= 5.0 x uln
Cardiac function
no uncontrolled angina or severe ventricular arrhythmias; no clinically significant pericardial disease; no history of myocardial infarction (mi) in the last year before registration; no class 3 or higher new york heart association congestive heart failure
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Virginia · Charlottesville, Virginia
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