OncoMatch/Clinical Trials/NCT06472388
Everolimus 5 mg vs 10 mg/Daily for Patients With Neuroendocrine Tumors
Is NCT06472388 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Everolimus 5 MG for neuroendocrine tumors.
Treatment: Everolimus 5 MG — Everolimus is approved in many countries to treat patients with advanced/metastatic well-differentiated neuroendocrine tumors (NET), providing median progression-free survival times of approximately 12 months across different types of NET. However, it is can cause severe adverse effects. Phase I trial demonstrated that a dose of 5mg/day/week was sufficient to inhibit cell proliferation by blocking the mTOR pathway. This is a randomized, open-label, phase II near-equivalence clinical trial of oral everolimus 5 mg vs 10 mg oral/daily and continuously in patients with Grade 1 or Grade 2 metastatic NET, with tumor progression or intolerance to at least one line of treatment and with radiological disease progression within 6 months.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Neuroendocrine Tumor
Pancreatic Cancer
Disease stage
Grade: 12
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Demographics
Prior therapy
Must have received:
At least one previous line of systemic treatment (suspended for more than 3 weeks).
Lab requirements
Blood counts
hemoglobin > 8 g/dl; neutrophils ≥ 1,500/mm³; platelets > 90,000/mm³
Kidney function
creatinine < 1.5 mg/dl
Liver function
ast and alt ≤ 2.5 x uln or ≤ 5 x uln for patients with liver metastases; bilirubin ≤ 1.5 x uln
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06472388 currently recruiting?
Yes, this trial is currently recruiting patients.
Is prior treatment required for enrollment?
Yes. Patients must have previously received .
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages