OncoMatch/Clinical Trials/NCT06470451
Confirmatory Study of Topical HyBryte™ vs. Placebo for the Treatment of CTCL
Is NCT06470451 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Hypericin for ctcl/ mycosis fungoides.
Treatment: Hypericin — To evaluate the use of HyBryte, a topical photosensitizing agent, to treat patients with patch/plaque phase cutaneous T-cell lymphoma (mycosis fungoides).
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Disease stage
Required: Stage IA, IB, IIA
Excluded: Stage IIB, III, IV
Prior therapy
Cannot have received: topical steroid
Patients receiving topical steroids or other topical treatments (eg, nitrogen mustard) on treated lesions for CTCL within 2 weeks of enrollment
Cannot have received: topical therapy (nitrogen mustard)
Patients receiving topical steroids or other topical treatments (eg, nitrogen mustard) on treated lesions for CTCL within 2 weeks of enrollment
Cannot have received: systemic steroid
Patients receiving systemic steroids, psoralen UVA radiation therapy (PUVA), narrow band UVB light therapy (NB-UVB) or carmustine (BCNU) or other systemic therapies for CTCL within 4 weeks of enrollment
Cannot have received: psoralen UVA radiation therapy
psoralen UVA radiation therapy (PUVA)
Cannot have received: narrow band UVB light therapy
narrow band UVB light therapy (NB-UVB)
Cannot have received: systemic therapy (carmustine)
carmustine (BCNU) or other systemic therapies for CTCL within 4 weeks of enrollment
Cannot have received: electron beam irradiation
Patients who have received electron beam irradiation within 3 months of enrollment
Lab requirements
Cardiac function
Screening ECG with QT interval >470 ms (corrected for heart rate using the Fridericia's formula) excluded
A Screening ECG with a QT interval >470 ms (corrected for heart rate using the Fridericia's formula)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Medical Dermatology Specialists · Phoenix, Arizona
- Mayo Clinic · Scottsdale, Arizona
- Therapeutics Clinical Research · San Diego, California
- University of South Florida · Tampa, Florida
- Northwestern University · Chicago, Illinois
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
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