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OncoMatch/Clinical Trials/NCT06456580

A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis (UPSTREAM MG)

Is NCT06456580 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Telitacicept for generalized myasthenia gravis.

Phase 3RecruitingVor BiopharmaNCT06456580Data as of May 2026

Treatment: TelitaciceptThe purpose of this study is to evaluate the efficacy and safety of telitacicept in the treatment of generalized myasthenia gravis.

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Extracted eligibility criteria

Biomarker criteria

Required: CHRNA1 antibody positive

Patients have positive antibodies against AChR

Required: MUSK antibody positive

Patients have positive antibodies against MuSK

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • University of Southern California · Los Angeles, California
  • University of California Irvine · Orange, California
  • University of California San Francisco (UCSF) · San Francisco, California
  • SFM Clinical Research · Boca Raton, Florida
  • Allied Biomedical Research Institute (ABRI) · Miami, Florida

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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