OncoMatch/Clinical Trials/NCT06448026
Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell Carcinoma
Is NCT06448026 recruiting? Yes, currently enrolling (Sep 2026). This Phase 2 trial studies multiple treatments including Cemiplimab and Cetuximab for locally recurrent oral cavity squamous cell carcinoma.
Treatment: Cemiplimab · Cetuximab — To learn if giving cemiplimab and cetuximab before salvage surgery can help to control recurrent oral cavity squamous cell carcinoma.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Targeted therapy
Cancer type
Head and Neck Squamous Cell Carcinoma
Biomarker criteria
Required: HPV wild-type (absence)
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: surgery — curative-intent
Must have received: radiation therapy — curative-intent
Lab requirements
Blood counts
hemoglobin ≥ 9 g/dl (transfusions permitted); absolute neutrophil count ≥ 1 x 10^9/ml; platelets ≥ 80 x 10^9/ml
Kidney function
creatinine clearance ≥ 30 ml/min as assessed by the cockcroft-gault equation
Liver function
ast and alt ≤ 3 x uln; total bilirubin ≤ 1.5 x uln or ≤ 3.0 x uln and primarily unconjugated if subject has a documented history of gilbert's syndrome or genetic equivalent
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- MD Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06448026 currently recruiting?
Yes, this trial is currently recruiting patients.
Is prior treatment required for enrollment?
Yes. Patients must have previously received surgery and radiation therapy.
Does this trial require HPV?
Yes, HPV wild-type is a required biomarker for enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages