OncoMatch/Clinical Trials/NCT06445062
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Is NCT06445062 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments for colorectal cancer.
Treatment: RMC-6236 · mFOLFOX6 regimen · bevacizumab · mFOLFIRINOX regimen · cetuximab · gemcitabine · nab-paclitaxel · RMC-9805 — The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The current subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol C: RMC-6236 + gemcitabine + nab-paclitaxel Subprotocol D: RMC-9805 with or without RMC-6236 + 5-fluorouracil-based regimens Subprotocol E: RMC-9805 with or without RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol F: RMC-9805 with or without RMC-6236 + gemcitabine + nab-paclitaxel
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Pancreatic Cancer
Gastric Cancer
Hepatocellular Carcinoma
Cholangiocarcinoma
Esophageal Carcinoma
Biomarker criteria
Required: HRAS g12d
Required: KRAS g12d
Required: NRAS g12d
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Lab requirements
Blood counts
Adequate organ function as outlined by the study
Kidney function
Adequate organ function as outlined by the study
Liver function
Adequate organ function as outlined by the study
Adequate organ function as outlined by the study
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Ironwood Cancer and Research Centers · Chandler, Arizona
- Mayo Clinic Hospital · Phoenix, Arizona
- HonorHealth Research Institute · Scottsdale, Arizona
- UC San Diego Moores Cancer Center · La Jolla, California
- Cedars-Sinai Cancer at Cedars-Sinai Medical Center · Los Angeles, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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