OncoMatch/Clinical Trials/NCT06433362
CMOEP in the Treatment of Untreated Peripheral T-cell Lymphoma
Is NCT06433362 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies CMOEP for peripheral t cell lymphoma.
Treatment: CMOEP — This is a prospective, single arm, multicenter study to evaluate the safety and efficacy of CMOEP in patients with untreated peripheral T-cell lymphoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
No previous treatment for PTCL, including chemotherapy, targeted therapy, immunotherapy, local radiotherapy for lymphoma (except for local radiotherapy to alleviate tumor related symptoms), surgical treatment.
Cannot have received: targeted therapy
No previous treatment for PTCL, including chemotherapy, targeted therapy, immunotherapy, local radiotherapy for lymphoma (except for local radiotherapy to alleviate tumor related symptoms), surgical treatment.
Cannot have received: immunotherapy
No previous treatment for PTCL, including chemotherapy, targeted therapy, immunotherapy, local radiotherapy for lymphoma (except for local radiotherapy to alleviate tumor related symptoms), surgical treatment.
Cannot have received: radiation therapy
Exception: local radiotherapy to alleviate tumor related symptoms
No previous treatment for PTCL, including chemotherapy, targeted therapy, immunotherapy, local radiotherapy for lymphoma (except for local radiotherapy to alleviate tumor related symptoms), surgical treatment.
Cannot have received: surgical treatment
No previous treatment for PTCL, including chemotherapy, targeted therapy, immunotherapy, local radiotherapy for lymphoma (except for local radiotherapy to alleviate tumor related symptoms), surgical treatment.
Lab requirements
Blood counts
ANC ≥1.5×10^9/L, PLT ≥75×10^9/L, HB ≥90 g/L (restriction may be relaxed in patients with bone marrow involvement: ANC ≥1.0×10^9/L, PLT ≥50×10^9/L, HB ≥75g/L)
Kidney function
Serum creatinine (Scr) ≤1.5X ULN
Liver function
ALT and AST ≤2.5X ULN (≤5X ULN with liver invasion); bilirubin (TBIL) ≤1.5X ULN (≤3X ULN with liver invasion)
Cardiac function
No long QTc syndrome or QTc interval >480 ms; no complete left bundle branch block, grade II or III AV block; no serious and uncontrolled arrhythmias requiring drug treatment; NYHA grade < II; LVEF ≥50%; no history of MI, unstable angina, severe unstable ventricular arrhythmia, clinically serious pericardial disease, or ECG evidence of acute ischemia or active conduction system abnormalities within 6 months
The following baseline laboratory criteria are required: Absolute neutrophil count (ANC) ≥1.5×10^9/L, Platelet count (PLT) ≥75×10^9/L, Hemoglobin(HB)≥ 90 g/L(Restriction may be relaxed in patients with bone marrow involvement, Absolute neutrophil count (ANC) ≥1.0×10^9/L, Platelet count (PLT) ≥50×10^9/L, Hemoglobin(HB)≥ 75g/L). Total Serum creatinine (Scr) ≤1.5X upper limit of normal (ULN); Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5X ULN(For patients with liver invasion ≤5X ULN), bilirubin (TBIL)≤1.5X ULN(For patients with liver invasion ≤3X ULN ). Heart function and disease meet one of the following conditions:1）Long QTc syndrome or QTc interval >480 ms;2）Complete left bundle branch block, grade II or III atrioventricular block;3）Serious and uncontrolled arrhythmias requiring drug treatment;4）New York Heart Association grade ≥ II;5）Cardiac ejection fraction (LVEF)<50%;6）A history of myocardial infarction, unstable angina pectoris, severe unstable ventricular arrhythmia or any other arrhythmia requiring treatment, a history of clinically serious pericardial disease, or ECG evidence of acute ischemia or active conduction system abnormalities within 6 months before recruitment.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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