OncoMatch/Clinical Trials/NCT06428409
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Is NCT06428409 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments for colorectal cancer.
Treatment: Sacituzumab tirumotecan · Fluorouracil (5-FU) · Leucovorin (LV) or levoleucovorin · Rescue medication · Supportive care measures · Cisplatin · Pembrolizumab — Researchers want to learn if sacituzumab tirumotecan (MK-2870) alone or with other treatments can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are either advanced (the cancer has spread to other parts of the body), or unresectable (the cancer cannot be removed with surgery). The goals of this study are to learn: * About the safety of sacituzumab tirumotecan alone or with other treatments and if people tolerate it * How many people have the cancer respond (get smaller or go away) to treatment
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Pancreatic Cancer
Cholangiocarcinoma
Disease stage
Required: Stage IV
Unresectable or metastatic colorectal cancer; Advanced or metastatic pancreatic ductal adenocarcinoma (PDAC); Advanced and/or unresectable biliary tract cancer (BTC)
Prior therapy
Must have received: systemic anticancer therapy
has received prior therapy for the cancer
Cannot have received: systemic anticancer therapy
Received prior systemic anticancer therapy including investigational agents within 4 weeks before starting study intervention
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UCLA ( Site 0317) · Los Angeles, California
- University of Colorado Anschutz Medical Campus ( Site 0299) · Aurora, Colorado
- University of Colorado Anschutz Medical Campus ( Site 0325) · Aurora, Colorado
- University of Colorado Anschutz Medical Campus ( Site 0326) · Aurora, Colorado
- Sibley Memorial Hospital ( Site 0310) · Washington D.C., District of Columbia
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
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