OncoMatch/Clinical Trials/NCT06421948
Linperlisib Combined With Chidamide in Patients With PTCL
Is NCT06421948 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including Linperlisib and chidamide and Linperlisib and chidamide for peripheral t-cell lymphoma.
Treatment: Linperlisib and chidamide · Linperlisib and chidamide · Linperlisib and chidamide · cyclophosphamide, doxorubicin/epirubicin, vincristine, and prednisone — The phase Ib part of this study aims to determine the recommended phase II dose （RP2D）of linperlisib in combination with chidamide for the treatment of peripheral T-cell lymphoma (PTCL). The phase IIa part is designed to evaluate the preliminary efficacy and safety of the linperlisib plus chidamide regimen in newly diagnosed PTCL patients. The phase IIb part compares the efficacy and safety of linperlisib combined with chidamide versus the standard CHOP (CHOP-like) regimen in newly diagnosed PTCL patients.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: PI3K inhibitor
Patients previously treated with PI3K inhibitor
Cannot have received: chidamide (chidamide)
Exception: phase Ib study is not limited by this item
Patients previously treated with chidamide (phase Ib study is not limited by this item)
Lab requirements
Blood counts
Hemoglobin ≥ 8 g/dL (≥5 mmol/l); Platelets ≥ 75 x 10E9/L; Absolute neutrophil count ≥ 1.0 x 10E9/L; Platelets ≥ 50 x 10E9/L permitted if documented bone marrow involvement
Kidney function
Serum creatinine ≤ 1.5 x ULN
Liver function
Serum bilirubin ≤ 1.5 x ULN; AST and/or ALT ≤ 2.5 x ULN, or ≤ 5 x ULN if elevation is due to hepatic involvement by lymphoma
Cardiac function
left ventricular ejection fraction (LVEF) ≥ 50%
Hemoglobin ≥ 8 g/dL (≥5 mmol/l); Platelets ≥ 75 x 10E9/L; Absolute neutrophil count ≥ 1.0 x 10E9/L; Platelets ≥ 50 x 10E9/L permitted if documented bone marrow involvement; Serum bilirubin ≤ 1.5 x upper limit of normal (ULN); Serum glutamic-oxaloacetic transaminase (AST) and/or serum glutamic-pyruvic transaminase (ALT) ≤ 2.5 x ULN, or ≤ 5 x ULN if elevation is due to hepatic involvement by lymphoma; Serum creatinine ≤ 1.5 x ULN; left ventricular ejection fraction (LVEF) ≥ 50%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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