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OncoMatch/Clinical Trials/NCT06420440

Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model

Is NCT06420440 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Lenvatinib and Tislelizumab for hcc.

Phase 2RecruitingChen XiaopingNCT06420440Data as of May 2026

Treatment: Lenvatinib · Tislelizumab · TislelizumabPrimary liver cancer is one of the most common malignant tumors in the world, and about 80%\~90% of primary liver cancers are pathologically characterized as hepatocellular carcinoma (HCC). Radical surgery is the main method for patients with HCC to obtain long-term survival. However, the early recurrence rate of high-risk HCC is very high, which seriously affects the overall therapeutic effect.

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Extracted eligibility criteria

Cancer type

Hepatocellular Carcinoma

Disease stage

Required: Stage BCLC-A TUMOR DIAMETER MORE THAN OR EQUAL TO 5CM, BCLC-B, BCLC-C (BCLC)

Enhanced MRI determines that the tumor is technically resectable but at high risk for recurrence(BCLC-A tumor diameter more than or equal to 5cm; BCLC-B; BCLC-C) ; without distant metastasis.

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Lab requirements

Liver function

child-pugh liver function score ≤ 7

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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