OncoMatch/Clinical Trials/NCT06415669
A Study of Paclitaxel Combined With Apatinib and Adebrelimab in Gastric/Gastroesophageal Junction Adenocarcinoma
Is NCT06415669 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Paclitaxel for and Adebrelimab for gastric/gastroesophageal junction adenocarcinoma.
Treatment: Paclitaxel for · Adebrelimab · Apatinib mesylate — To evaluate the initial efficacy and safety of paclitaxel for injection (albumin-bound) in combination with apatinib mesylate and adebrelimab in the treatment of locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma following the progression of previous immunotherapy.
Check if I qualifyExtracted eligibility criteria
Cancer type
Gastric Cancer
Esophageal Carcinoma
Biomarker criteria
Excluded: HER2 (ERBB2) overexpression or amplification
HER2-positive patients [excluded]
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: immunotherapy — first-line
Patients who have received at least first-line immunotherapy progression or intolerance in the past
Cannot have received: taxane (paclitaxel)
Exception: Neoadjuvant or adjuvant taxoid drugs allowed if disease progression >6 months after last chemotherapy
Patients who have previously received paclitaxel chemotherapy; Patients with neoadjuvant or adjuvant treatment with taxoid drugs and disease progression more than 6 months after the last chemotherapy were excluded
Lab requirements
Blood counts
ANC ≥1.5x10^9/L (no G-CSF in past 14 days); Platelets ≥100x10^9/L (no transfusion in past 14 days); Hemoglobin >90g/L (no transfusion or erythropoietin in past 14 days)
Kidney function
Serum creatinine ≤1.5× ULN and creatinine clearance ≥40 ml/min
Liver function
Total bilirubin ≤1.5× ULN; AST/ALT ≤2.5× ULN (≤5× ULN with liver metastasis)
Cardiac function
Myocardial enzyme profile within normal range (unless abnormality not clinically significant); Good coagulation function (INR or PT ≤1.5× ULN)
The major organs function normally and meet the following criteria...
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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