OncoMatch/Clinical Trials/NCT06415318
TIP Regimen Combined With Triplizumab Neoadjuvant Therapy for Locally Advanced Penile Cancer
Is NCT06415318 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Paclitaxel + Ifosfamide + Cisplatin & Toripalimab for penile cancer.
Treatment: Paclitaxel + Ifosfamide + Cisplatin & Toripalimab — Primary Objective: To evaluate the efficacy and safety of TIP (paclitaxel + ifosfamide + cisplatin) combined with Toripalimab as a neoadjuvant treatment in locally advanced penile cancer
Check if I qualifyExtracted eligibility criteria
Treatments studied
Chemotherapy
Cancer type
Penile Carcinoma
Disease stage
Required: Stage T4, ANY N, ANY T, N3
Clinical Stage is Locally advanced penile cancer (T4, any N stage; or any T stage, N3)
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Demographics
Prior therapy
Cannot have received: chemotherapy
Exception: time from last chemotherapy to relapse > 12 months
No prior chemotherapy for newly diagnosed or relapsed patients or the time from the last chemotherapy to relapse should be longer than 12 months
Cannot have received: experimental drug
Previously received any other experimental drug treatment within 4 weeks before enrollment
Lab requirements
Blood counts
hemoglobin(hb) >= 80g/l; white blood cell count >= 3.0x10^9/l; neutrophil count >= 1.5x10^9/l; platelet count >= 100x10^9/l
Liver function
ast, alt, alp <= 2.5 uln; total bilirubin <= 1.5 uln
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06415318 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior chemotherapy, experimental drug disqualifies patients from enrollment.
What disease stage is eligible?
Stage T4, ANY N or ANY T, N3 is required.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Is this trial open to female patients?
No. This trial enrolls male patients only.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages