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OncoMatch/Clinical Trials/NCT06413498

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

Is NCT06413498 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments for multiple myeloma.

Phase 3RecruitingKite, A Gilead CompanyNCT06413498Data as of May 2026

Treatment: Anitocabtagene Autoleucel · Cyclophosphamide · Fludarabine · Pomalidomide · Bortezomib · Dexamethasone · Daratumumab · CarfilzomibThe goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug. The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM.

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Max 3 prior lines
Min 1 prior line

Must have received: immunomodulatory drug

Received 1 to 3 prior lines of antimyeloma therapy, including an immunomodulatory drug (IMiD) and an anti-cluster of differentiation 38 (CD38) monoclonal antibody (mAb). A minimum of 2 consecutive cycles of an IMiD ... is required.

Must have received: anti-CD38 monoclonal antibody

Received 1 to 3 prior lines of antimyeloma therapy, including an immunomodulatory drug (IMiD) and an anti-cluster of differentiation 38 (CD38) monoclonal antibody (mAb). A minimum of 2 consecutive cycles of ... an anti-CD38 mAb ... is required.

Cannot have received: BCMA-targeted therapy

Prior B-cell maturation antigen (BCMA)-targeted therapy

Cannot have received: T-cell engager therapy

Prior T-cell engager therapy

Cannot have received: CAR-T cell therapy

Prior CAR therapy or other genetically modified T-cell therapy

Cannot have received: autologous stem cell transplant

Exception: within 12 weeks before randomization

Prior auto-SCT within 12 weeks before randomization

Cannot have received: allogeneic stem cell transplant

Prior allogeneic stem cell transplant (allo-SCT)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Banner MD Anderson Cancer Center · Gilbert, Arizona
  • Mayo Clinic Hospital · Gilbert, Arizona
  • City of Hope (City of Hope National Medical Center, City of Hope Medical Center) · Duarte, California
  • USC/Norris Comprehensive Cancer Center · Los Angeles, California
  • University of California Davis Comprehensive Cancer Center · Sacramento, California

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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