OncoMatch/Clinical Trials/NCT06413498
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma
Is NCT06413498 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments for multiple myeloma.
Treatment: Anitocabtagene Autoleucel · Cyclophosphamide · Fludarabine · Pomalidomide · Bortezomib · Dexamethasone · Daratumumab · Carfilzomib — The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and an immunomodulatory drug. The primary objective of this study is to compare the efficacy of anitocabtagene autoleucel versus SOCT in participants with RRMM.
Check if I qualifyExtracted eligibility criteria
Cancer type
Multiple Myeloma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: immunomodulatory drug
Received 1 to 3 prior lines of antimyeloma therapy, including an immunomodulatory drug (IMiD) and an anti-cluster of differentiation 38 (CD38) monoclonal antibody (mAb). A minimum of 2 consecutive cycles of an IMiD ... is required.
Must have received: anti-CD38 monoclonal antibody
Received 1 to 3 prior lines of antimyeloma therapy, including an immunomodulatory drug (IMiD) and an anti-cluster of differentiation 38 (CD38) monoclonal antibody (mAb). A minimum of 2 consecutive cycles of ... an anti-CD38 mAb ... is required.
Cannot have received: BCMA-targeted therapy
Prior B-cell maturation antigen (BCMA)-targeted therapy
Cannot have received: T-cell engager therapy
Prior T-cell engager therapy
Cannot have received: CAR-T cell therapy
Prior CAR therapy or other genetically modified T-cell therapy
Cannot have received: autologous stem cell transplant
Exception: within 12 weeks before randomization
Prior auto-SCT within 12 weeks before randomization
Cannot have received: allogeneic stem cell transplant
Prior allogeneic stem cell transplant (allo-SCT)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Banner MD Anderson Cancer Center · Gilbert, Arizona
- Mayo Clinic Hospital · Gilbert, Arizona
- City of Hope (City of Hope National Medical Center, City of Hope Medical Center) · Duarte, California
- USC/Norris Comprehensive Cancer Center · Los Angeles, California
- University of California Davis Comprehensive Cancer Center · Sacramento, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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