OncoMatch/Clinical Trials/NCT06404697
Boost Irradiation to the Supraclavicular Area Among High Risk cN3c Breast Cancer Patients
Is NCT06404697 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for breast cancer.
cN3c breast cancer with ipsilateral supraclavicular (SCV) lymph nodal (SCLN) metastasis is known to have a dismal prognosis. Currently, the combined-modality therapy consisting of primary systemic therapy (PST), subsequent local and/or systemic therapy based on response is the standard of care. However, the value of giving radiotherapy (RT) boost to SCV region remains uncertain in cN3c patients. This study aimed to assess the efficacy and safety of RT boost to the SCV area in high-risk cN3c breast cancer patients based on nodal response following PST.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Biomarker criteria
Required: ESR1 expression (testing required; no eligibility threshold specified)
Availability of hormonal receptor (ER/PR)...status for the primary breast lesion
Required: PR (PGR) expression (testing required; no eligibility threshold specified)
Availability of hormonal receptor (ER/PR)...status for the primary breast lesion
Required: HER2 (ERBB2) expression (testing required; no eligibility threshold specified)
Availability of...HER2...status for the primary breast lesion
Required: MKI67 expression (testing required; no eligibility threshold specified)
Availability of...Ki-67 status for the primary breast lesion
Disease stage
Required: Stage CN3C
Clinical diagnosis of cN3c; Patients with T4 staging of the primary tumor [excluded]
Prior therapy
Must have received: neoadjuvant therapy — neoadjuvant
Receipt of neoadjuvant therapy, guided by the attending physician and current treatment guidelines
Must have received: curative-intent breast cancer surgery — post-neoadjuvant
Undergoing curative-intent breast cancer surgery post-neoadjuvant therapy
Cannot have received: radiation therapy to the neck, chest, or ipsilateral axilla
History of prior radiation therapy to the neck, chest, or ipsilateral axilla
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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