OncoMatch/Clinical Trials/NCT06403111
FMT+Immunotherapy+Chemotherapy As First-line Treatment for Driver-gene Negative Advanced NSCLC
Is NCT06403111 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Fecal Microbiota Transplantation (FMT)+chemotherapy+immunotherapy for non-small cell lung cancer.
Treatment: Fecal Microbiota Transplantation (FMT)+chemotherapy+immunotherapy — This study plans to reconstruct intestinal microecology through fecal microbiota transplantation (FMT), and combine with standard first-line therapy to enhance the anti-tumor immune effect at the same time, thereby extending the progression-free survival of patients and improving the prognosis of patients.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Required: EGFR wild-type
the driver gene is negative
Required: ALK wild-type
the driver gene is negative
Required: ROS1 wild-type
the driver gene is negative
Required: BRAF wild-type
the driver gene is negative
Required: MET wild-type
the driver gene is negative
Required: RET wild-type
the driver gene is negative
Required: HER2 (ERBB2) wild-type
the driver gene is negative
Required: KRAS wild-type
the driver gene is negative
Required: PD-L1 (CD274) expression < 50% (< 50%)
PD-L1 expression < 50%
Disease stage
Required: Stage IIIB, IIIC, IV
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: systemic intravenous anti-tumor therapy
Have not received systemic intravenous anti-tumor therapy before
Lab requirements
Blood counts
ANC ≥1.5×10^9/L; PLT ≥75×10^9/L; HGB ≥90 g/L (no blood transfusion or erythropoietin dependence within 14 days)
Kidney function
serum creatinine ≤1.5x ULN or creatinine clearance ≥50 mL/min; urine protein <2+; if ≥2+, 24-hour urine protein <1g
Liver function
serum total bilirubin (TBIL) ≤2x ULN; ALT and/or AST ≤5x ULN; serum albumin ≥28 g/L; ALP ≤5x ULN
adequate organ and bone marrow function, laboratory examination within 7 days prior to enrollment meets the following requirements...
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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