OncoMatch/Clinical Trials/NCT06392971
Deep-sea Fish Oil for Prevention of Acute Radiation-induced Esophagitis
Is NCT06392971 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Deep-sea fish oil for radiation toxicity.
Treatment: Deep-sea fish oil — Purpose：To observe and evaluate the clinical efficacy and safety of deep-sea fish oil in preventing acute radiation-induced esophagitis (ARIE). Methods and Materials：A total of 120 patients with esophageal cancer treated with radiotherapy were randomly assigned (1:1) to treatment or control group. In the treatment group, 1g deep-sea fish oil was oral administrated prophylactically twice a day，the control group was blank control. The clinical efficacy of deep-sea fish oil on prevention of ARIE was evaluated by comparing the differences in the occurrence time, the grade and incidence of ARIE. Additionally, the change in nutritional status was also investigated. Hemanalysis, liver function, kidney function changes， and adverse reactions were compared before and after treatment to evaluate the safety of deep-sea fish oil.
Check if I qualifyExtracted eligibility criteria
Cancer type
Esophageal Carcinoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: radiation therapy
Lab requirements
Blood counts
Bone marrow function not contraindicated by radiotherapy and chemotherapy
Kidney function
Kidney function not contraindicated by radiotherapy and chemotherapy
Liver function
Liver function not contraindicated by radiotherapy and chemotherapy
Cardiac function
Cardiopulmonary function not contraindicated by radiotherapy and chemotherapy
Liver and kidney function, bone marrow function and cardiopulmonary function are not contraindicated by radiotherapy and chemotherapy
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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