OncoMatch/Clinical Trials/NCT06376526
IMMUNOPLANT for Newly Diagnosed Multiple Myeloma
Is NCT06376526 recruiting? Yes, currently enrolling (Sep 2026). This Phase 2 trial studies Linvoseltamab for multiple myeloma.
Treatment: Linvoseltamab — The purpose of this study is to determine whether Linvoseltamab therapy in patients with newly diagnosed multiple myeloma will convert the disease status from minimal residual disease (MRD)-positive to MRD-negative, and increase the length of time that the disease is controlled. The researchers also want to find out the effects (good and bad) that Linvoseltamab has on participants and the condition.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Cancer type
Multiple Myeloma
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: combination therapy (triplet or quadruplet) containing at least two of: immunomodulatory drug, proteasome inhibitor, anti-CD38 — initial therapy for NDMM
received a triplet or quadruplet based initial combination therapy containing at least two of the following: Immunomodulatory drug (IMiD), proteosome inhibitor (PI), and/or anti-cluster of differentiation 38 (anti-CD38)
Cannot have received: systemic therapies for multiple myeloma other than initial IMiD/PI/anti-CD38-based combination therapy
Exception: limited cycles of other induction therapies (e.g., CyBorD or pulse dexamethasone prior to main induction is allowed)
Patients who have received prior systemic therapies for MM other than initial IMiD/PI/anti-CD38-based combination therapy (receiving limited cycles of other induction therapies, eg, cyclophosphamide, bortezomib and dexamethasone (CyBorD) or pulse dexamethasone prior to main induction is allowed).
Cannot have received: high-dose melphalan with autologous stem cell transplant (HDM-ASCT)
Exclusions include high-dose melphalan with autologous stem cell transplant (HDM-ASCT)
Cannot have received: allogeneic stem cell transplant
Exclusions include ... allogeneic stem cell transplant (SCT)
Lab requirements
Blood counts
ANC ≥1,000/mcL (unless ethnic/cyclic neutropenia or due to MM); Platelets ≥50,000/mcL; Hemoglobin ≥8 g/dL (transfusions permitted)
Kidney function
Serum creatinine ≤ 1.5 X ULN (except if due to myeloma) or eGFR ≥30 mL/min/1.73 m2 (measured GFR can also be used)
Liver function
Serum total bilirubin ≤ 1.5 X ULN or direct bilirubin ≤ ULN for patients with total bilirubin levels > 1.5 ULN (except patients with Gilbert's syndrome who must have a total bilirubin of <3 X ULN); AST and ALT ≤ 2.5 X ULN
Adequate organ function, which is defined as follows: ... (see inclusion criterion 6 for details)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Miami · Miami, Florida
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT06376526 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior systemic therapies for multiple myeloma other than initial IMiD/PI/anti-CD38-based combination therapy, high-dose melphalan with autologous stem cell transplant (HDM-ASCT), allogeneic stem cell transplant disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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