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OncoMatch/Clinical Trials/NCT06371586

Neo-Sequence 2:NCT Plus Anti-angiogenesis Therapy and Immunotherapy for LADGC

Is NCT06371586 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Albumin paclitaxel+SOX+BEV+ PD-1 monoclonal antibody therapy for gastric cancer.

Phase 2RecruitingCancer Institute and Hospital, Chinese Academy of Medical SciencesNCT06371586Data as of Jun 2026Location: China

Treatment: Albumin paclitaxel+SOX+BEV+ PD-1 monoclonal antibody therapyThe regimen of Albumin paclitaxel+SOX+BEV neoadjuvant therapy lasted for 6 cycles, during which PD-1 monoclonal antibody therapy was interspersed for 4 cycles for locally advanced diffuse gastric cancer.

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Extracted eligibility criteria

Treatments studied

Chemotherapy

Albumin paclitaxel+SOX+BEV+ PD-1 monoclonal antibody therapy

Cancer type

Gastric Cancer

Disease stage

Required: Stage T3-4NANYM0 (AJCC 8th edition)

T3-4NanyM0 gastric cancer or gastroesophageal junction cancer (refer to AJCC staging, 8th edition)

Performance status

ECOG 0–1(Restricted strenuous activity)

Demographics

Ages ≤ 75

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Lab requirements

Blood counts

Neutrophils >1.5G/L, Hb >90g/L, PLT >100G/L

Kidney function

Cr <1.0ULN

Liver function

ALT and AST <2.5ULN; TBIL <1.5 ULN

Cardiac function

Left ventricular ejection fraction >60%

Neutrophils>1.5G/L, Hb>90g/L, PLT>100G/L; ALT and AST<2.5ULN; TBIL<1.5 ULN; Cr<1.0ULN; Left ventricular ejection fraction>60%

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT06371586 currently recruiting?

Yes, this trial is currently recruiting patients.

Can patients have received prior systemic therapy?

No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.

What disease stage is eligible?

Stage T3-4NANYM0 is required.

Is there an age limit?

Yes. Patients must be 75 years or younger.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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