OncoMatch/Clinical Trials/NCT06363006
Combination of Cardonizumab Injection and TKI Second Line Therapy for Advanced Hepatocellular Cancer
Is NCT06363006 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies TKI+Cardunilimab for hepatocellular carcinoma.
Treatment: TKI+Cardunilimab — The goal of this clinical trial is to evaluate the efficacy and safety of cardonilizumab injection combined with TKI in second-line treatment of advanced hepatocellular carcinoma. The main questions it aims to answer are: * Objective response rate (ORR) for evaluation * Disease Control Rate (DCR); Duration of relief (DoR); Progression free survival (PFS); Total survival time (OS); Safety。
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Hepatocellular Carcinoma
Disease stage
Required: Stage BCLC STAGE C, STAGE B THAT PROGRESSES IRREMEDIABLY AFTER SURGERY AND/OR LOCAL TREATMENT (BCLC)
Barcelona Clinic Liver Cancer (BCLC) stage C; It is not suitable for radical surgery and/or local treatment or stage B that progresses irremediably after surgery and/or local treatment.
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Must have received: systemic antitumor therapy
Progression or intolerance after receiving at least one systemic antitumor therapy for hepatocellular carcinoma prior to initial administration
Cannot have received: liver transplantation
History of liver transplantation.
Lab requirements
Liver function
child-pugh level a
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06363006 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior liver transplantation disqualifies patients from enrollment.
What disease stage is eligible?
Stage BCLC STAGE C or STAGE B THAT PROGRESSES IRREMEDIABLY AFTER SURGERY AND/OR LOCAL TREATMENT is required.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages