OncoMatch/Clinical Trials/NCT06353061
Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer
Is NCT06353061 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including Metformin and Chemotherapy for cervical cancer.
Treatment: Metformin · Chemotherapy — This is a prospective, single-center, phase II, randomized, window-of-opportunity trial initiated by researchers. The research hypothesis is that metformin can improve the level of hypoxia in locally advanced cervical cancer and further improve progression-free survival. The study aims to compare the improvement of tumor hypoxia with synchronous chemoradiotherapy with or without metformin, using CA-IX PET/CT and radiation positioning spectral CT to evaluate tumor hypoxia, screening hypoxic patients for inclusion in the study, and comparing the effects of synchronous chemoradiotherapy with or without metformin on the degree of hypoxia and progression-free survival in the two groups of patients.
Check if I qualifyExtracted eligibility criteria
Cancer type
Cervical Cancer
Disease stage
Required: Stage IIA, IIB, IIIA, IIIB, IVA (FIGO)
FIGO stage IB2-IVA
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: chemotherapy
Cannot have received: pelvic radiotherapy
Lab requirements
Blood counts
Hemoglobin ≥90g/L; no severe hematopoietic dysfunction
Kidney function
no significant renal dysfunction; eGFR ≥45 ml‧min-1‧1.73 m-2
Liver function
no significant hepatic dysfunction; serum transaminases ≤3x ULN; no liver failure or alcohol poisoning
Cardiac function
no significant cardiac dysfunction
Hemoglobin ≥90g/L (blood transfusions allowed); no severe hematopoietic dysfunction, and no significant cardiac, pulmonary, hepatic, renal dysfunction, or immune deficiency; Renal insufficiency with eGFR <45 ml‧min-1‧1.73 m-2, and acute conditions that may lead to renal impairment such as dehydration, severe infectious diseases, shock, etc.; Serum transaminases exceeding 3 times the upper limit of normal, liver failure, alcohol poisoning.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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