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OncoMatch/Clinical Trials/NCT06352008

To Evaluate the Efficacy and Safety of Anlotinib Hydrochloride Capsule in Postoperative Non-pCR Patients With Non-small Cell Lung Cancer

Is NCT06352008 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Anlotinib for non-small cell lung cancer.

Phase 2RecruitingTianjin Medical University Cancer Institute and HospitalNCT06352008Data as of May 2026

Treatment: AnlotinibTo explore the effectiveness of anlotinib hydrochloride capsule in postoperative non-pCR non-small cell lung cancer patients with adjuvant intensive therapy

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Biomarker criteria

Required: EGFR wild-type

Subjects are known to have genetic abnormalities that have been approved for targeted drug therapy (non-squamous cell carcinoma subjects are required to have EGFR or ALK gene tested or provide previous test reports during the screening period)

Required: ALK wild-type

Subjects are known to have genetic abnormalities that have been approved for targeted drug therapy (non-squamous cell carcinoma subjects are required to have EGFR or ALK gene tested or provide previous test reports during the screening period)

Disease stage

Required: Stage IIA, IIB, IIIA (AJCC/UICC 8th edition)

Patients with stage IIA-IIIA NSCLC ... AJCC/UICC 8th edition

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Must have received: anti-PD-1 therapy — neoadjuvant

previously received PD-1/PD-L1 inhibitors combined with chemotherapy neoadjuvant therapy

Must have received: anti-PD-L1 therapy — neoadjuvant

previously received PD-1/PD-L1 inhibitors combined with chemotherapy neoadjuvant therapy

Must have received: chemotherapy — neoadjuvant

previously received PD-1/PD-L1 inhibitors combined with chemotherapy neoadjuvant therapy

Must have received: surgery — definitive (R0 resection)

underwent R0 resection for curative purposes before surgery

Cannot have received: Chinese patent medicines with anti-tumor indications (compound Cantharides capsule, Kangai injection, Kanglaite capsule/injection, Aidi injection, Bruceae oil injection/capsule, Xiaoaipingtablet/injection, hualbufatin capsule)

Within 2 weeks before starting the administration, it has been treated with Chinese patent medicines (including compound Cantharides capsule, Kangai injection, Kanglaite capsule/injection, Aidi injection, Bruceae oil injection/capsule, Xiaoaipingtablet/injection, hualbufatin capsule, etc.) with anti-tumor indications specified in the NMPA approved drug instructions

Lab requirements

Blood counts

Kidney function

Liver function

The main organs function well and meet the standards

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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