OncoMatch/Clinical Trials/NCT06312137
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Is NCT06312137 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments for non small cell lung cancer.
Treatment: Sacituzumab tirumotecan · Pembrolizumab · Cisplatin · Pemetrexed · Gemcitabine · Carboplatin · Paclitaxel · Rescue medication — This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Biomarker criteria
Required: ALK wild-type
Required: PD-L1 (CD274) any tested (testing required; no eligibility threshold specified)
Required: EGFR wild-type
Required: TACSTD2 any tested (testing required; no eligibility threshold specified)
Disease stage
Required: Stage II, IIIA, IIIB (WITH NODAL INVOLVEMENT [N2])
Prior therapy
Cannot have received: neoadjuvant therapy
Has received prior neoadjuvant therapy for their current NSCLC diagnosis
Cannot have received: systemic anticancer therapy
Has received prior systemic anticancer therapy including investigational agents within 4 weeks before the first dose of study intervention
Cannot have received: radiotherapy
Has received prior radiotherapy within 2 weeks of start of study intervention, or radiation-related toxicities, requiring corticosteroids
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060) · Little Rock, Arkansas
- Highlands Oncology Group-Research Department ( Site 0062) · Springdale, Arkansas
- Beverly Hills Cancer Center ( Site 0070) · Beverly Hills, California
- The Angeles Clinic and Research Institute ( Site 0040) · Los Angeles, California
- The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate ( Site 0079) · Los Angeles, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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