OncoMatch/Clinical Trials/NCT06304857
CardioPROTECTion with Dapagliflozin in Breast Cancer Patients Treated with AnthrAcycline - PROTECTAA TRIAL
Is NCT06304857 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Dapagliflozin for breast cancer.
Treatment: Dapagliflozin — The purpose of this study is to evaluate the effect of dapagliflozin on the incidence of cancer therapeutics-related cardiac dysfunction in patients with breast cancer receiving anthracycline treatment.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Disease stage
Required: Stage I, II, III
Excluded: Stage IV
Lab requirements
Blood counts
Anemia with Hemoglobin < 9 g/dl excluded
Kidney function
eGFR < 25 ml/min/1.73m2 according to CKD EPI excluded; Kidney failure > G2 (according to KDIGO classification) excluded
Liver function
Alanine transaminase or aspartate transaminase levels above 2.5 times the local norm excluded; Liver disorders, Child-Pugh score > 4 excluded
Cardiac function
Left ventricular ejection fraction < 50% at screening excluded; severe valvular heart disease, history of clinically significant arrhythmia, history of stroke, cardiomyopathy, pulmonary hypertension, uncontrolled arterial pressure or systolic pressure < 80 mmHg at screening excluded
Left ventricular ejection fraction < 50% at the time of the screening. Severe valvular heart disease. A history of clinically significant arrhythmia, including atrial fibrillation regardless of type (at discretion of the investigator). A history of stroke. Cardiomyopathy: congenital, post-inflammatory, toxic, infiltrative (e.g. amyloidosis, sarcoidosis, haemochromatosis), postnatal or hypertrophic. Pulmonary hypertension. Uncontrolled arterial pressure or systolic pressure < 80 mmHg at screening (at the discretion of the investigator). Alanine transaminase or aspartate transaminase levels above 2.5 times the local norm. Anemia with Hemoglobin < 9 g/dl. Kidney failure > G2 (according to KDIGO classification). Liver disorders, Child-Pugh score > 4.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify