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OncoMatch/Clinical Trials/NCT06300424

Neoadjuvant Almonertinib Followed by Chemo-immunotherapy in II-IIIB EGFR-mutant NSCLC

Is NCT06300424 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including almonertinib and Carboplatin for non small cell lung cancer.

Phase 2RecruitingGuangdong Provincial People's HospitalNCT06300424Data as of May 2026

Treatment: almonertinib · Carboplatin · Nab paclitaxel — Phase II, single-arm, open-label study that assess clinical feasibility and safety of neoadjuvant almonertinib followed by 3 cycles neoadjuvant adebrelimab plus chemotherapy in EGFR-mutant stage IIA-IIIB NSCLC followed by surgery, adjuvant treatment was upon investigators' decisions.

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Extracted eligibility criteria

Cancer type

Small Cell Lung Cancer

Biomarker criteria

Required: EGFR exon 19 deletion

harboring EGFR mutation: Ex19del, L858R, T790M, G719X, Exon20 insertions, S768I or L861Q

Required: EGFR L858R

harboring EGFR mutation: Ex19del, L858R, T790M, G719X, Exon20 insertions, S768I or L861Q

Required: EGFR T790M

harboring EGFR mutation: Ex19del, L858R, T790M, G719X, Exon20 insertions, S768I or L861Q

Required: EGFR G719X

harboring EGFR mutation: Ex19del, L858R, T790M, G719X, Exon20 insertions, S768I or L861Q

Required: EGFR exon 20 insertion

harboring EGFR mutation: Ex19del, L858R, T790M, G719X, Exon20 insertions, S768I or L861Q

Required: EGFR S768I

harboring EGFR mutation: Ex19del, L858R, T790M, G719X, Exon20 insertions, S768I or L861Q

Required: EGFR L861Q

harboring EGFR mutation: Ex19del, L858R, T790M, G719X, Exon20 insertions, S768I or L861Q

Disease stage

Required: Stage II, IIIA, IIIB

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: any treatment to non small cell lung cancer other than this regimen

previous treatment to non small cell lung cancer other than this regimen

Cannot have received: thoracic radiotherapy

received thoracic radiotherapy

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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