OncoMatch/Clinical Trials/NCT06290193
Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Cytoreductive Surgery
Is NCT06290193 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Acute Normovolemic Hemodilution/ANH for ovarian cancer.
Treatment: Acute Normovolemic Hemodilution/ANH — Participants will be scheduled for primary cytoreductive surgery as part of their standard care. Before surgery, participants will be assigned by chance to a study group. Depending on which group they are in, they will receive either acute normovolemic hemodilution/ANH during surgery or standard surgical management during surgery. The researchers think acute normovolemic hemodilution/ANH may decrease the need for allogenic blood transfusion/ABT in people having primary cytoreductive surgery.
Check if I qualifyExtracted eligibility criteria
Cancer type
Ovarian Cancer
Disease stage
Required: Stage IIIC, IV
Lab requirements
Blood counts
platelet count ≥100,000/mcL, INR ≤1.5 (if not on coumadin), preoperative hemoglobin concentration ≥10 mg/dl within 45 days of surgery
Kidney function
creatinine ≤1.6 mg/dl
Liver function
bilirubin ≤2 mg/dl, ALT ≤75 U/L in the absence of biliary tract obstruction
Cardiac function
no active coronary artery disease unless stress study shows no reversible ischemia and normal LV function within 45 days of surgery; no history of congestive heart failure; no uncontrolled hypertension
Preoperative hemoglobin concentration ≥10 mg/dl within 45 days of surgery; Abnormal coagulation parameters (INR >1.5 not on coumadin, or platelet count <100,000 mcL); Evidence of hepatic metabolic disorder (bilirubin >2 mg/dl, ALT >75 U/L in the absence of biliary tract obstruction); A history of renal dysfunction (Cr >1.6 mg/dl); A history of active coronary artery disease; A history of congestive heart failure; A history of uncontrolled hypertension
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Memoral Sloan Kettering at Basking Ridge (Limited Protocol Activities) · Basking Ridge, New Jersey
- Memorial Sloan Kettering Monmouth (Limited protocol activities) · Middletown, New Jersey
- Memorial Sloan Kettering Bergen (Limited protocol activities) · Montvale, New Jersey
- Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities) · Commack, New York
- Memorial Sloan Kettering Westchester (Limited protocol activities) · Harrison, New York
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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