OncoMatch

OncoMatch/Clinical Trials/NCT06289673

Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

Is NCT06289673 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies multiple treatments for acute lymphoblastic leukemia.

Phase 4RecruitingSt. Jude Children's Research HospitalNCT06289673Data as of May 2026

Treatment: Dexamethasone · Vincristine · Daunorubicin · Intrathecal triple therapy (methotrexate + hydrocortisone + cytarabine) · Methotrexate · Cytarabine — The goal of this study is to provide sufficient therapy during the time a patients' B-cell Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LLy) risk category is being determined. The term "risk" refers to the chance of the ALL or LLy coming back after treatment. Primary Objectives * To provide sufficient therapy to enable testing of newly diagnosed acute lymphoblastic leukemia/lymphoma and mixed phenotype acute leukemia/lymphoma tumor samples to determine eligibility and appropriate risk stratification for SJALL therapeutic studies. * To develop a central database of genomic and clinical findings. Secondary Objectives * To assess event free and overall survival data of patients enrolled on this study.

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Extracted eligibility criteria

Cancer type

Acute Lymphoblastic Leukemia

Non-Hodgkin Lymphoma

Acute Myeloid Leukemia

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: cancer directed therapy

Exception: up to 1 dose of intrathecal chemotherapy, 1 dose of vincristine, or emergency radiotherapy due to organ compromising malignant mass; no exclusion for prior steroid therapy

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Rady Children's Hospital · San Diego, California
  • Saint Francis Children's Hospital · Tulsa, Oklahoma
  • St. Jude Children's Research Hospital · Memphis, Tennessee

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