OncoMatch/Clinical Trials/NCT06274515
A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies
Is NCT06274515 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies non-drug interventions for breast cancer.
This study will evaluate mechanisms of resistance to anti-breast cancer therapies in tumor and blood samples from participants with human epidermal growth factor receptor (HER2) positive, hormone receptor (HR) positive or triple negative breast cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Breast Carcinoma
Biomarker criteria
Required: HER2 (ERBB2) overexpression
Diagnosis of HER2+ ... breast cancer
Required: ESR1 expression
Diagnosis of ... HR+ (for cohort R1) ... breast cancer
Required: PR (PGR) expression
Diagnosis of ... HR+ (for cohort R1) ... breast cancer
Required: ESR1 loss
triple negative breast cancer (for cohort T1)
Required: PR (PGR) loss
triple negative breast cancer (for cohort T1)
Required: HER2 (ERBB2) wild-type
triple negative breast cancer (for cohort T1)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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