OncoMatch/Clinical Trials/NCT06249321
mFOLFIRINOX Plus Radiotherapy to Patients With CA19-9-normal Advanced Pancreatic Cancer Refractory to Chemotherapy
Is NCT06249321 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies mFOLFIRINOX plus IMRT for pancreatic cancer.
Treatment: mFOLFIRINOX plus IMRT — The purpose of this study is to evaluate the efficacy of mFOLFIRINOX plus radiotherapy to Patients with CA19-9-normal Advanced Pancreatic Cancer refractory to chemotherapy.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Pancreatic Cancer
Biomarker criteria
Required: FUT3 CA19-9 ≤ 37 U/mL (≤ 37 U/mL)
Baseline serum CA19-9 ≤ 37 U/mL
Required: CEACAM5 CEA ≤ 5.2 ng/mL (≤ 5.2 ng/mL)
CEA≤ 5.2 ng/mL
Required: MUC16 CA125 ≤ 35 U/mL (≤ 35 U/mL)
CA125 ≤ 35 U/mL
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Demographics
Prior therapy
Must have received: chemotherapy
Patients who are refractory to at least one line of chemotherapy
Cannot have received: radiotherapy
who have not received radiotherapy
Lab requirements
Kidney function
Renal insufficiency or dialysis [excluded]
Adequate organ performance based on laboratory blood tests. Renal insufficiency or dialysis [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT06249321 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior radiotherapy disqualifies patients from enrollment.
Does this trial require FUT3?
Yes, FUT3 CA19-9 ≤ 37 U/mL is a required biomarker for enrollment.
Does this trial require CEACAM5?
Yes, CEACAM5 CEA ≤ 5.2 ng/mL is a required biomarker for enrollment.
Does this trial require MUC16?
Yes, MUC16 CA125 ≤ 35 U/mL is a required biomarker for enrollment.
Is there an age limit?
Yes. Patients must be 80 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages