OncoMatch/Clinical Trials/NCT06244771
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Is NCT06244771 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies FMC-376 for advanced solid tumors with kras g12c mutations.
Treatment: FMC-376 — The goal of this clinical trial is to evaluate FMC-376 in participants with advanced solid tumors with KRAS G12C mutations. This clinical trial will be conducted in 3 parts: Phase 1A (Dose Escalation), Phase 1B (Dose Expansion), and Phase 2 (Cohort Expansion). Multiple dose levels in participants with advanced solid tumors will be evaluated.
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Small Cell Lung Cancer
Colorectal Cancer
Pancreatic Cancer
Biomarker criteria
Required: KRAS g12c
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: standard therapy
Received and progressed or been intolerant to prior standard therapy OR standard therapy is considered inappropriate OR an investigational agent is considered standard of care
Lab requirements
Blood counts
Kidney function
Liver function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of California San Diego (UC San Diego) Health - Jacobs Medical Center - Moores Cancer Center · La Jolla, California
- University of California Irvine (UCI) - Chao Family Comprehensive Cancer Center · Orange, California
- University of California San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center · San Francisco, California
- Florida Cancer Specialists and Research Institute · Lake Mary, Florida
- Northwest Cancer Centers · Dyer, Indiana
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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