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OncoMatch/Clinical Trials/NCT06235203

Neoadjuvant vs Adjuvant in Locally Advanced Recurrent NPC

Is NCT06235203 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments including Neoadjuvant therapy,Toripalimab and Adjuvant therapy in experimental group,Toripalimab for recurrent nasopharyngeal carcinoma.

Phase 3RecruitingEye & ENT Hospital of Fudan UniversityNCT06235203Data as of May 2026

Treatment: Neoadjuvant therapy,Toripalimab · Adjuvant therapy in experimental group,ToripalimabA multicenter randomized controlled study of surgery combined with neoadjuvant and adjuvant therapy for locally advanced recurrent nasopharyngeal carcinoma in comparison to surgery combined with adjuvant therapy

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Extracted eligibility criteria

Cancer type

Head and Neck Squamous Cell Carcinoma

Disease stage

Required: Stage RT2, RT3, RT4

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Must have received: radiation therapy — definitive

≥6months from the accomplishment of radical radiation to recurrence

Cannot have received: radiation therapy

Exception: previously only 1 course of radiotherapy

previously only 1 course of radiotherapy

Cannot have received: radioactive particle implantation

History of radioactive particle planting

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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