OncoMatch/Clinical Trials/NCT06229483
The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies
Is NCT06229483 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS for brain tumor.
Treatment: TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS — The goal of this clinical trial is to test the effect of a drug called tranexamic acid (TXA) on reducing blood loss in participants undergoing surgery to remove brain tumors. The main questions it aims to answer are: 1. Does TXA 20 mg/kg IV bolus of TXA, and 1 mg/kg/hr infusion of TXA reduce the amount of estimated blood loss during surgery? 2. Does TXA 20 mg/kg IV bolus of TXA, and 1 mg/kg/hr infusion of TXA prevent re-operation, disability or death related to bleeding inside the head during and after surgery? Participants are randomized to receive 20 mg/kg IV bolus of TXA or matching placebo within 30 minutes of start of surger, and then 1 mg/kg/hr infusion of TXA or matching from the start of surgery to end of surgery. Treatment allocation is blinded. Investigator will compare the two treatment arms to see whether there are differences in the amount of blood loss during surgery and bleeding-related complications. Investigators will also monitor for any side effects of TXA.
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Prior therapy
Cannot have received: embolization
Lab requirements
Blood counts
pre-existing coagulopathy such as hemophilia, Von Willebrand disease, and clotting factor deficiencies [excluded]
Kidney function
renal impairment and eGFR <60 ml/min/1.73 m2 or end stage renal disease currently on dialysis [excluded]
Patients with known pre-existing coagulopathy such as hemophilia, Von Willebrand disease, and clotting factor deficiencies. Patients with renal impairment and eGFR <60 ml/min/1.73 m2 as determined by the lab or calculated by using the Cockcroft Gault formula or end stage renal disease currently on dialysis.
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