OncoMatch/Clinical Trials/NCT06215976
The Nephroprotective Effect of Metformin With Cisplatin in Bladder Cancer
Is NCT06215976 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies Metformin Hydrochloride 500 MG for muscle-invasive bladder carcinoma.
Treatment: Metformin Hydrochloride 500 MG — The goal of this clinical trial is to evaluate the protective effect of metformin on nephrotoxicity of cisplatin in patients with bladder cancer. The main questions it aims to answer are: * To determine protective effect of metformin on structural and functional kidney injury caused by cisplatin in patients with bladder cancer. * To evaluate the safety of combining cisplatin and metformin on patients with bladder cancer
Check if I qualifyExtracted eligibility criteria
Cancer type
Urothelial Carcinoma
Prior therapy
Lab requirements
Kidney function
stable renal function: eGFR is above 60 ml/min/1.73 m2; unstable renal function (increase in serum creatinine of 0.3 mg/dL or greater suddenly in 48 hours) excluded
Patients with stable renal function: eGFR is above 60 ml/min/1.73 m2; Unstable renal function (defined as an increase in serum creatinine of 0.3 mg/dL or greater suddenly in 48 hours according to the acute kidney injury network (AKIN) classification [excluded])
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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